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Carboplatin and capecitabine for anal cancer

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Study record managers: refer to the Data Element Definitions if submitting registration or results information. RATIONALE: Drugs used in chemotherapy, such as capecitabine, epirubicin, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug combination chemotherapy may kill more tumor cells. PURPOSE: This phase I trial is studying the side effects and best dose of capecitabine when given together with epirubicin and carboplatin in treating patients with progressive, unresectable, or metastatic cancer. Patients receive epirubicin hydrochloride IV over 2 hours and carboplatin IV over 30 minutes on day 1 and oral capecitabine twice daily on days , , and
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Consent forms for SACT (Systemic Anti-Cancer Therapy)

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Consent forms for SACT (Systemic Anti-Cancer Therapy) | Cancer Research UK

Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly. However, longer survival and less toxicity was observed in patients receiving carboplatin and paclitaxel, according to findings presented at the ESMO Congress in Munich, Germany. Furthermore, medical need exists for this disease where, there currently is no consensus on management, leaving SCCA patients with poor overall survival OS. InterAACT was a randomised phase II, selection trial with pick the winner design that aimed to establish a standard of care by comparing combined fluoropyrimidine plus platinum agents, which was often considered standard first-line therapy with taxanes, which have shown activity in this patient population. Patients were enrolled from more than 50 centres located internationally. The patients were stratified according to performance status PS , extent of disease, HIV status, and country.
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Platinum Agents – Cisplatin, Carboplatin, Oxaliplatin, Newer Platins

Metrics details. While there is limited published evidence to substitute capecitabine CAP for 5-FU, the objectives of the study were to describe the toxicity, dose intensity and outcomes of a sequential cohort of patients treated with chemo-radiotherapy with CAP and MCC in a population-based setting. Dose intensity was calculated by comparing delivered versus planned radiation and chemotherapy treatments and toxicity was retrospectively graded according to standard protocol-specified criteria. Among 66 eligible patients, median planned dose of radiation was
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Study record managers: refer to the Data Element Definitions if submitting registration or results information. Overall survival OS. Progression free survival PFS.
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